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High Quality Ion Channel Drug Discovery
 Catalogue
2011/12
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Drug Screening … CNS fields:
neuropathy, pain, mood,
memory, sleep, epilepsy
… Cardiovascular fields:
arrhythmia, hypertension
… Further fields:
immunology,
metabolism, PNS
… Techniques include
patch-clamping and
fluorescence assays
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 | hERG Safety
… High
quality GLP testing
… ICH guided test
strategies
… High throughput quality hERG screening
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Design of Stable Cell Lines …
Production of test
systems for high throughput screening
… From
molecular
biology to functional validation
… Seamless
documentation
from DNA to assay
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 | Good Laboratory Practice … Study
completion
according to GLP principles
… Quarterly QAU
inspections of
test facility
… Archiving of study records for at
least 10
years
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Fields of interest:
Ion channel screening, glp, hERG, hERG channel, potassium channel, HEK,
CHO, CRO, S7A S7B, QT prolongation, cardiac action potential.
QT prolongation, pharmacology, safety pharmacology, hERG screening,
Swissmedic, in vivo, in vitro, preclinical safety assessment.
patch-clamp, IKr, cisapride, terfenadine, astemizole, grepafloxacin, QT
interval, cardiac arrhythmias, FDA, myocytes, hERG liability.
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